When we talk about severe male factor infertility, or in essence, zero sperm count, Larry, what does that mean, and what can be done about that?
LAWRENCE GRUNFELD, MD: It's always a shock for the couple because there is no way that the couple can sense that there is a zero sperm count. Typically, when there is a zero sperm count, the man has a normal sensation for ejaculation. I think it's important here to have the couple understand that there are two components to the semen. There is a liquid component, which they can sense, and then there is the microscopic component which is made in the testicles, which they would have no way of knowing about. So these couples have no way of knowing there is a problem, but when we evaluate the sperm under the microscope, we see normal fluid, but no sperm inside the fluid.
The other subcategory is the dry ejaculate. Sometimes couples present and the husband knows that there is no fluid coming out in the ejaculation. That's a more obvious problem to the couple.
In either one of those cases, the guy has to be sent directly to a urologist with a speciality in male fertility such as Steve.
MARK POCHAPIN, MD: So what happens now? The man comes to you Steve. What can be done?