GRAEME MOYLE, MD: When we look at combinations that involve nonnucleoside drugs like efavirenz or nevirapine, they tend to cause changes in the lipids also, but mostly what we're seeing there is a rise in the good cholesterol, the HDL cholesterol and only a more modest increase in the LDL cholesterol.
ANNOUNCER: Until recently, most protease inhibitors seemed to elevate blood lipids. But there are now drugs that may not carry that same risk.
EDWIN DEJESUS, MD: For the most part, all protease inhibitors have been associated with elevation in triglyceride and cholesterol.
But recently, new protease inhibitors in the market has been developed that actually do not have this particular complication. For example, a new protease inhibitor with the name of Reyataz was developed and has not been associated with an increase in the triglycerides and cholesterol.
ANNOUNCER: When lipid levels do rise, lifestyle changes are often a doctor's first recommendation.
KATHLEEN SQUIRES, MD: When we are coming up with treatment strategies for elevated serum lipids, the first thing that we always do before we go to drugs is to put patients on a diet that's low in fat, and to exercise them.
ANDREW CARR, MD: Diet and exercise have a role to play. I mean I do say to patients, walk to work and use stairs and don't eat and do regular exercise. The results are not always that successful. Although it's clearly the easiest place to start, a lot more needs to be done in most people.